Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p237 | (1) | WCRB2014

Involvement of peroxisomes in steroid synthesis in Leydig cells and their role for male fertility

Kamalyan Lilit , Vijayan Vijith , Brauns Ann-Kristin , Colasante Claudia , Schuler Gerhard , Luers Georg H , Baumgart-Vogt Eveline

Introduction: Peroxisomes are ubiquitous organelles, which play an essential role in human physiology. Besides other metabolic pathways, peroxisomes are involved in β-oxidation of fatty acids, ROS-metabolism, and cholesterol synthesis, wherefore alterations of peroxisomal metabolism might affect steroid metabolism and the regulation of corresponding signaling pathways. Indeed male patients with peroxisomal dysfunction exhibit either cryptorchidism or a range of testicular...